The Guyanese, who have lost all of their matches so far, will oppose French Guiana at Andre Kampervene Stadium.
French Guiana defeated Suriname 2-1 on the opening day while the locals lost 1-5 to Suriname.
The men from the colony of France are yet to be beaten having put aside Antigua 2-1 as well.
Richie Richards will replace injured and first choice goal keeper Ronson Williams.
Richards was between the uprights when Suriname trashed the side 5-1.
Guyana are on a come back trail in world football after a miserable 2008 season.
The Guyana Football Federation (GFF) has made several changes to the team but so far the youthful Jaguars unit is having a rocky start to their rebuilding process.
Today’s game will start at 5pm local time.