Paterson was named in the starting team by coach Andy Robinson yesterday and will be presented with a specially-commissioned cap to mark the occasion after the match at the Millennium Stadium.
The 31-year-old made his debut in 1999 and has developed into the most accurate goalkicker in the international game.
“He’s a great professional both on the pitch and also off it,” Robinson said of Paterson.
“He thoroughly deserves the honour and the tributes bestowed upon him because of the way that he’s performed consistently with a number of different coaches.”
Robinson made three changes from the team beaten 18-9 at home by France on Sunday, with flyhalf Phil Godman, centre Max Evans and prop Moray Lowe all dropped.
TACTICAL KICKING
Dan Parks takes over the number 10 shirt with Rory Lamont coming in on the left wing and his brother Sean moving to outside centre.
Key prop Euan Murray is back after missing the France game because of his decision not to play on Sunday for religious reasons.