Firefighters are battling a blaze at Castle Hotel located on Chapel Street, New Amsterdam, Berbice.
The fire service said that at about 4:37 p.m., Water tenders #74 and #87, along with a Land Rover and their crews under the command of Divisional Officer Harry, promptly responded to the scene, with the first unit arriving at 4:40 p.m.
The top floor of the three-storey building is engulfed in flames, while the second floor has been destroyed.
All occupants were reportedly safely evacuated from the building and there has been no report of injuries.
Firefighters are trying to prevent the fire from spreading to nearby buildings.